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Human chorionic gonadotropin (HCG or hCG) in a low dose, which may be injected after completed ovarian stimulation, is used for final maturation and/or release of oocytes. Ovulation will occur between 38 and 40 hours after a single HCG injection. It is also used in in vitro fertilization, where it makes the follicles perform their final maturation. A transvaginal oocyte retrieval is then performed at a time usually between 34 and 36 hours after hCG injection, that is, just prior to when the follicles would rupture. HCG injection confers a risk of ovarian hyperstimulation syndrome. Recombinant HCG (rHCG), recombinant luteinizing hormone (rLH) and urine-derived hCG (uHCG) are equally effective in achieving final follicular maturation in IVF with regards to pregnancy rates and risk of ovarian hyperstimulation syndrome. Therefore, urine-derived hCG (uHCG) is regarded as the best choice for final oocyte maturation triggering in IVF due to availability and cost.