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Tamoxifen (TMX), sold under the brand name Nolvadex among others.
Tamoxifen is used to treat infertility in women with anovulatory disorders. It is given at days 3–7 of a woman’s cycle.
Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic-pituitary-adrenal axis (via ER antagonism) and thereby increasing the secretion of luteinizing hormone and follicle-stimulating hormone and increasing testicular testosterone production. Tamoxifen did eventually receive marketing approval as a fertility treatment.
Tamoxifen is available as a generic medication.